Abstract: To explore the change of the carotid artery function in diabetic patients using high-frequency ultrasound,sixty-five diabetic patients and forty subjects as normal control group were examined with high-frequency ultrasound,the diabetic patients were divided into hypertensive group(35 cases) and normo-tensive group(30cases).Two-dimentional ultrasound was used to observe the intima-media thickness(IMT);M-mode ultrasound was used to record the movement extent change between systolic and diastolic period of the anterior and the posterior wall of common carotid artery;the diameters of systolic and diastolic period were also measured,and the stiffeness index,distensibility and compliance,acceleration and dec-eleration which were corrected with pluse pressure and heart rates(Aci and Dci) calculated.Compared with the control group,the diabetic groups have thicker IMT,higher stiffeness index,lower distensibility,compliance,Aci and Dci in each diabetic group(P<0.01).There was markedly higher IMT and stiffeness index and lower distensibility,compliance,Aci and Dci in hypertensive diabetic group than in normoten-sive diabetic group(P<0.01).IMT correlated with age,stiffeness index,distensibility,compliance,Aci and Dci.High-frequency ultrasound plays an important role in evaluating change of the carotid artery function in diabetic patients.