Abstract: Ultrasound can be used to monitor the dimensional architectural change of muscle clearly,and it is a useful tool to study skeletal muscle.We defined the dimensional architectural change of muscle con-tinuously extracted from ultrasound images as "sonomyography(SMG)".In this paper,we used the ultrasound measurement of motion and elasticity system,which could synchronously and continuously acq-uire different data including the ultrasound images,force or moment,angle,EMG signals,and so on without disturbance,to record the ultrasound images and surface EMG signals sampled from the extensor carpi radialis with the wrist angles during the cycle of wrist flexion-extension.The feasibility of studying the skeletal muscle in motion with multi-signals was discussed,and the results illuminate the advantage to study the properties of skeletal muscle with multi-signals.