Abstract: High Intensity Focused Ultrasound ( HIFU ) is a new type of tumor treatment method. Cavitation effect is one of the important biological effects in HIFU treatment. In order to ensure the safety and effectiveness of HIFU treatment, it is necessary to consider the mechanical properties of the target tissue and reasonably to select the HIFU irradiation dose When formulating the HIFU clinical treatment plan to control the intensity of cavitation activity.This paper explores the influence of tissue mechanical properties on cavitation effect. Large bubbles appear in the focal region under the action of HIFU, and the impact scattering caused by large bubbles is beneficial to stimulate cavitation and reduce the cavitation threshold. The simulation results show that as the Young 's modulus of the tissue increases, the expansion of bubble growth in the focal region decreases, thus reducing the impact scattering and increasing the cavitation threshold. The passive cavitation monitoring system is used to monitor the cavitation of isolated tissues. The fat with loer Young 's modulus can reach the steady-state cavitation threshold and inertial cavitation threshold at 42W and 56W sound power, and has the highest cavitation activity intensity. Pork and bovine liver with higher Young 's modulus reach the steady-state cavitation threshold at 56W and 77W sound power, and reach the inertial cavitation threshold at 77W and 84W sound power, respectively. And, the intensity of cavitation activity also decreases. The experimental results show that the tissue cavitation threshold is proportional to Young 's modulus, and the cavitation intensity is inversely proportional to Young 's modulus.This study provides a reference for the formulation of HIFU clinical treatment plan, Which is of great significance for reducing the adverse effects of HIFU treatment and improving the clinical safety of HIFU.