Abstract: Uniaxial compressive strength of rock is one of the most basic and important parameters in geotechnical engineering. It has become a research hotspot in geotechnical field to establish a fast, convenient and economic prediction method. In order to obtain the prediction model of the schist uniaxial compressive strength, the regression analyses of uniaxial compressive strength with P-wave velocity, S-wave velocity, P-wave modulus, S-wave modulus, dynamic elastic modulus and static elastic modulus are carried out based on the data of ultrasonic test and uniaxial compression test for schist samples of collected in a mine in Fujian Province. Five regression models of linear, logarithmic, polynomial, exponential and power functions are established respectively. The results show that all other parameters, except dynamic modulus of elasticity, are not suitable for predicting the uniaxial compressive strength of the schist due to the influences of spatial variability and anisotropy. Finally, the linear regression model based on the dynamic modulus of elasticity is determined to be the most reasonable, reliable and convenient prediction model of the schist uniaxial compressive strength based on the fitting degree, connotation parameter, dimensional balance, testing method and significance analysis. The results can provide reference and help for the relevant theoretical research and engineering application.