Abstract: In this paper, particle swarm optimization (PSO) is used to optimize the sound absorption performance of honeycomb micro perforated absorber. Aperture, perforation rate and back cavity depth of the microperforated panel in three honeycomb cores are set as the optimized design variables. The optimal structural parameters of absorber in a wide frequency range are obtained by taking absorption coefficient and absorption frequency band of the absorber as the optimization objectives. The sound absorption performances calculated under the three conditions of threeparameter optimization, two-parameter optimization and conventional structural parameters are compared. The results show that the sound absorption performance of the absorber optimized by three-parameter is much better than that of the conventional structure parameters. Meanwhile, the results in two-parameter optimization of perforation rate and cavity depth are closest to that in three-parameter optimization of perforation rate and cavity depth and aperture. In addition, the influence of each parameter of the microperforated panel of the absorber on the optimization results is studied.