Abstract: High Intensity Focused Ultrasound (HIFU) has been shown a promising prospect in clinical applications. HIFU ablation technique is widely used because it could heat the target tumor tissues instantaneously up to more than 60℃, resulting in irreversible coagulation necrosis, without affecting the normal tissue outside the target area. At present, the single-frequency high-intensity focused ultrasound is mainly used in ultrasound therapy, but the main limitation of its clinical application is that the target tissue ablation time is longer and the risk of the normal tissue damage outside the target area is greater. Shortening the target tissue ablation time is vital for improving the efficiency of HIFU treatment and better clinical application. Based on summarizing the characteristics of HIFU transducers and the influencing factors of HIFU therapy, this paper reviews the research progress in the application of different types of dual-frequency HIFU transducers to enhancing cavitation and shortening the ablation time of target tissue.